I found a quick workaround for my Homelab so I can get patched past Update 2a and hopefully not have to deal with this anymore:
Here is the error I got when trying to update:
[root@localhost:~] esxcli software profile update -p ESXi-7.0U2c-18426014-standard \ > -d https://hostupdate.vmware.com/software/VUM/PRODUCTION/main/vmw-depot-index.xml [InstallationError] Failed to query file system stats: Errors: Cannot open volume: cause = Errors: Cannot open volume: Please refer to the log file for more details.
I ran the following:
esxcli storage core adapter rescan -a
Once completed I was able to patch my ESXi to 7.0U2c 18426014